Sirens and the boom of explosions, possible from Israeli interceptors, could be heard in the sky over Jerusalem and Tel Aviv early Saturday.
AP journalists in Tel Aviv could see what appeared to be at least two Iranian missiles hit the ground, but there was no immediate word of casualties.
The Israeli military said another long-range Iranian missile attack was taking place and urged civilians, already rattled by the first wave of projectiles, to head to shelter. Around three dozen people were wounded by that first wave.
The Iranian outlet Nour News, which has close links with the paramilitary Revolutionary Guard, said a fresh wave was being launched.
AP